Sugar acids and derivatives
Medchemexpress LLC PROTAC BET-binding moiety 1 | 2093387-77-8 | 80.4% | 487.51 | C25H25N7O4 | 1 ML
PROTAC BET-binding moiety 1 is a small-molecule intermediate used in the synthesis of high-affinity BET (bromodomain and extra-terminal) inhibitors. Supplied as a ready-to-use DMSO solution (10 mM, 1 mL), it is intended for medicinal chemistry and PROTAC development targeting BRD2, BRD3, BRD4, and BRDT.
- Ready-to-use 10 mM solution in DMSO.
- Suitable for synthesis of BET inhibitors and PROTACs.
- Molecular formula C25H25N7O4 and molecular weight 487.51.
- Reported purity 80.4%.
- CAS number 2093387-77-8 for unambiguous identification.
Medchemexpress LLC BET-IN-14 | 2243669-93-2 | C30H37N7O2 | 5 MG
BET-IN-14 is an orally active pan BET inhibitor with an IC50 of 5.35 nM, demonstrating anti-cancer activity. It is intended for research use only.
- Orally active pan BET inhibitor
- Exhibits anti-cancer activity
- High purity (99.07%)
- Solid, light yellow to yellow appearance
- Soluble in DMSO (100 mg/mL)
- Effective against various cancer cell lines (average IC50: 174.7 nM)
- Inhibits tumor growth in MV-4-11 xenograft models
Cayman Chemical D-Glucuronic Acid, Purity: ≥95%, CAS: 6556-12-3, 50 g
A metabolite of glucose; a component of proteoglycans; levels are increased in fibroblasts isolated from patients with ISSD or Salla disease
![Medchemexpress LLC 2,6-dichloro-N-[2-(cyclopropanecarbonylamino)-4-pyridinyl]benzamide | 1258292-64-6 | ≥98.0% | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000231850.png-250.jpg)
Medchemexpress LLC 2,6-dichloro-N-[2-(cyclopropanecarbonylamino)-4-pyridinyl]benzamide | 1258292-64-6 | ≥98.0% | 50 MG
GDC-046 is a small-molecule TYK2 inhibitor for research use. It is potent, selective, and orally bioavailable, with reported Ki values of 4.8 nM for TYK2 and 0.7 nM, 0.7 nM, and 0.4 nM for JAK1, JAK2, and JAK3, respectively.
- Potent and selective TYK2 inhibitor with low nanomolar Ki values.
- Orally bioavailable small molecule suitable for in vitro and in vivo studies.
- High purity material (≥98%).
- Molecular formula C16H13Cl2N3O2 and molecular weight 350.2 g/mol.
- Intended for research use only; not for human or clinical use.
- Supplied as a 50 MG quantity.
Medchemexpress LLC (S)-Ibuprofen acyl-β-D-glucuronide | 98649-76-4 | 98.5% | 382.40 | 1 MG
(S)-Ibuprofen acyl-β-D-glucuronide is a compound used to study the metabolism and pharmacokinetics of S-ibuprofen, which is a non-steroidal anti-inflammatory drug. It is an acylglucuronic acid metabolite produced from S-ibuprofen in the liver. This product is intended for research use only.
- Used for studying metabolism.
- Used for pharmacokinetic research.
- Derived from a common anti-inflammatory drug.
- Metabolite produced in the liver.
Medchemexpress LLC 2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide | 1258292-64-6 | 99.8% | 1 ML
GDC-046 (2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide) is a potent, selective, orally bioavailable TYK2 inhibitor with reported Ki values of 4.8 nM (TYK2), 0.7 nM (JAK1), 0.7 nM (JAK2), and 0.4 nM (JAK3). Supplied for research use, available as a 10 mM solution in DMSO (1 mL) or as solid material.
- Potent, selective TYK2 inhibitor with low-nanomolar activity against JAK family kinases.
- Molecular weight 350.2 g/mol; formula C16H13Cl2N3O2.
- CAS 1258292-64-6; purity 99.8%.
- Physical form solid, off-white to yellow; also supplied as 10 mM solution in DMSO (1 mL).
- Solubility in DMSO 62.5 mg/mL (178.47 mM); ultrasonic assistance recommended.
- Storage: solid at 4 °C; in solvent store at -80 °C (up to 6 months) or -20 °C (up to 1 month); protect from light.
Medchemexpress LLC Interferon alpha/beta receptor 1 Antibody (YA3833) | Predicted band size: 64 kDa; Observed band size: 110-130 kDa | 50 UL
The Interferon alpha/beta receptor 1 Antibody (YA3833) is a mouse-derived, non-conjugated IgG1 monoclonal antibody that targets Interferon alpha/beta receptor 1. This antibody is intended for research use only. Interferon alpha/beta receptor 1 (IFNAR1), in conjunction with IFNAR2, forms the heterodimeric receptor crucial for type I interferon signaling. Binding of type I interferons initiates the JAK-STAT signaling cascade, which leads to the transcriptional regulation of interferon-regulated genes that mediate the interferon response.
- Host: Mouse
- Clonality: Monoclonal antibody
- Species reactivity: Human, mouse
- Conjugation: Non-conjugated
- Isotype: IgG1
- Appearance: Liquid
- Formulation: Supplied in PBS with 0.05% sodium azide
- Purity: Affinity purified
- Storage: Stored at -20°C for 1 year. Avoid repeated freeze/thaw cycles.
- Applications: WB, IHC-P, FC, ELISA
Apexbio Technology LLC Beta-Amyloid (1-11) 190436-05-6 25mg
Beta-Amyloid (1-11) (CAS 190436-05-6) is a synthetic peptide fragment derived from the N-terminus of the amyloid precursor protein comprising the amino acid sequence H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-OH This peptide represents a portion of the beta-amyloid (A ) sequence implicated in amyloidogenic pathways associated with neurodegenerative processes particularly Alzheimer s disease Beta-Amyloid (1-11) is utilized in research to investigate amyloid aggregation dynamics immunogenic epitope mapping within the A region and the biochemical properties of amyloidogenic peptides It serves as a molecular tool in studies examining the early stages of A processing clearance and interactions with cellular components
Medchemexpress LLC D-Arabinopyranose | 28697-53-2 | 25 MG
D-Arabinopyranose is a monosaccharide and an analytical standard intended for research and analytical applications. It has been shown to exhibit strong growth inhibition against Caenorhabditis elegans with an IC50 of 7.5 mM.
- Analytical standard for research and analytical applications
- Exhibits strong growth inhibition against Caenorhabditis elegans
- Commonly used in qualitative, quantitative, and methodological research experiments
- Suitable for techniques such as HPLC, GC, and MS
- Reference standard supplied for assay
Medchemexpress LLC 4-Methylumbelliferyl 1g
4-Methylumbelliferyl octanoate is a octoate 4-Methylumbelliferyl octanoate can be used as a s ubstrate of hog pancreatic lipase[1]
![Medchemexpress LLC Sar-[D-Phe8]-des-Arg9-bradykinin | 126959-88-4 | MFCD05662308 | 100.0% | 975.10 | C47H66N12O11 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000244662.png-250.jpg)
Medchemexpress LLC Sar-[D-Phe8]-des-Arg9-bradykinin | 126959-88-4 | MFCD05662308 | 100.0% | 975.10 | C47H66N12O11 | 25 MG
Sar-[D-Phe8]-des-Arg9-bradykinin is a synthetic peptide agonist of the bradykinin B1 receptor used in pharmacological research to study receptor activation and contractile responses. It is supplied as a white to off-white solid with high purity and a defined amino acid sequence.
- High purity suitable for analytical and biological assays.
- Molecular weight 975.10 and formula C47H66N12O11.
- Sequence: {Sar}-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe.
- Stable as powder when stored sealed at -80°C (2 years) or -20°C (1 year).
- Available in multiple sizes, including 25 MG.
Medchemexpress LLC PROTAC BET Degrader-10 | 1957234-97-7 | 99.4% | 783.29 | 1 ML
PROTAC BET Degrader-10 (dBET37) is a potent BET protein BRD4 degrader, connected by ligands for Cereblon and BRD4, with a DC50 of 49 nM. This compound utilizes PROTAC technology, containing two different ligands connected by a linker; one for an E3 ubiquitin ligase and the other for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Potent BET protein BRD4 degrader
- Connected by ligands for Cereblon and BRD4
- DC50 of 49 nM
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
- For research use only
- Components include a BRD4(BD1BD2) ligand, a Cereblon ligand, and a linker
- Appearance is a solid
- Color is off-white to light yellow
Medchemexpress LLC 4-Methylumbelliferyl-α-d-mannoside | 28541-83-5 | 99.3% | 338.31 | 5 MG
4-Methylumbelliferyl-α-d-mannoside is a fluorescent substrate for α-D-mannosidase. For research use only.
- Fluorescent substrate for α-D-mannosidase.
- For research use only.
Medchemexpress LLC Integrin alpha X bet 50ug
Integrin -X/ -2 is a receptor for fibrinogen that recognizes GPR sequences It plays a key role in inflammatory responses particularly in monocyte adhesion and chemotaxis Integrin alpha X beta 2 Protein Human (HEK293 Flag His) is a recombinant protein dimer complex containing human-derived Integrin alpha X beta 2 protein expressed by HEK293 with C-His C-Flag labeled tag
Medchemexpress LLC Protac α-synuclein degrader 3 | 2412273-77-7 | ≥98.0% | C51H68N6O11S2 | 10MG
PROTAC α-synuclein degrader 3 is a proteolysis-targeting chimera developed for research applications to induce ubiquitination and proteasomal degradation of α-synuclein, useful in Parkinson's disease model studies. It has documented in vitro and in vivo formulation solubility and recommended storage conditions for stable handling.
- Selective α-synuclein degrader that promotes ubiquitination and proteasomal degradation.
- Demonstrated to reduce α-synuclein levels (≈65% reduction at 1 μM).
- Soluble in DMSO at 100 mg/mL with ultrasonic assistance.
- Formulatable for in vivo dosing in multiple vehicle systems at ≥2.5 mg/mL.
- Stable when stored as powder at 4°C; in solution store at -80°C (6 months) or -20°C (1 month).
- For research use only; not intended for clinical or therapeutic use.